Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

@article{Pearson2006SwitchingFI,
  title={Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.},
  author={E. Pearson and I. Flechtner and P. Nj{\o}lstad and M. Małecki and S. Flanagan and B. Larkin and F. Ashcroft and I. Klime{\vs} and E. Codner and V. Iotova and A. S. Slingerland and J. Shield and J. Robert and J. Holst and P. Clark and S. Ellard and O. S{\o}vik and M. Polak and A. Hattersley},
  journal={The New England journal of medicine},
  year={2006},
  volume={355 5},
  pages={
          467-77
        }
}
BACKGROUND Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP)) channel, cause 30 to 58 percent of cases of diabetes diagnosed in patients under six months of age. Patients present with ketoacidosis or severe hyperglycemia and are treated with insulin. Diabetes results from impaired insulin secretion caused by a failure of the beta-cell K(ATP) channel to close in response to increased intracellular ATP. Sulfonylureas close the K(ATP… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to switch from insulin to oral sulfonylurea in patients with apparent type 1 diabetes or maturity onset diabetes in the young that are insulin treated… Expand
ConditionsChildhood Diabetes Mellitus, Insulin-dependent Diabetes Mellitus, Maturity Onset Diabetes of the Young, Type 1, (+1 more)
InterventionDrug
Interventional Clinical Trial
The purpose of this study is to investigate long term response of sulfonylurea and glucose control in children with diabetes due to mutations in ABCC8 that have been switched from… Expand
ConditionsPermanent Neonatal Diabetes Mellitus
InterventionDrug
Interventional Clinical Trial
The understanding of the molecular mechanisms of neonatal diabetes has deeply changed the therapy of patients carrying mutations in the K-ATP channel. Indeed, those patients are not… Expand
ConditionsNeonatal Diabetes Secondary to Mutation in the Potassium Channel
InterventionDrug
Interventional Clinical Trial
The purpose of this study is to investigate long term response of sulfonylurea and glucose control in children with diabetes due to mutations in KCNJ11 that have been switched from… Expand
ConditionsPermanent Neonatal Diabetes Mellitus
InterventionDrug
Permanent neonatal diabetes by a new mutation in KCNJ11: unsuccessful switch to sulfonylurea.
Improved Diabetic Control During Oral Sulfonylurea Treatment in Two Children with Permanent Neonatal Diabetes Mellitus
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.
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Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.
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