Switching from body surface area-based to fixed dosing for the investigational proteasome inhibitor ixazomib: a population pharmacokinetic analysis.

@article{Gupta2015SwitchingFB,
  title={Switching from body surface area-based to fixed dosing for the investigational proteasome inhibitor ixazomib: a population pharmacokinetic analysis.},
  author={Neeraj Gupta and Yuan Zhao and A M Hui and D E Esseltine and Karthik Venkatakrishnan},
  journal={British journal of clinical pharmacology},
  year={2015},
  volume={79 5},
  pages={789-800}
}
AIMS This population pharmacokinetic analysis of the investigational oral proteasome inhibitor ixazomib assessed the feasibility of switching from body surface area (BSA)-based to fixed dosing, and the impact of baseline covariates on ixazomib pharmacokinetics. METHODS Data were pooled from 226 adult patients with multiple myeloma, lymphoma or solid tumours in four phase 1 studies, in which ixazomib dosing (oral/intravenous, once/twice weekly) was based on BSA. Population pharmacokinetic… CONTINUE READING
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