Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos.

@article{Jurberg2013SwitchingAP,
  title={Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos.},
  author={Arnon Dias Jurberg and Rita Aires and Irma Varela-Lasheras and Ana N{\'o}voa and Moises Mallo},
  journal={Developmental cell},
  year={2013},
  volume={25 5},
  pages={451-62}
}
The vertebrate body is made by progressive addition of new tissue from progenitors at the posterior embryonic end. Axial extension involves different mechanisms that produce internal organs in the trunk but not in the tail. We show that Gdf11 signaling is a major coordinator of the trunk-to-tail transition. Without Gdf11 signaling, the switch from trunk to tail is significantly delayed, and its premature activation brings the hindlimbs and cloaca next to the forelimbs, leaving extremely short… CONTINUE READING
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