Switching antipsychotics: Imaging the differential effect on the topography of postsynaptic density transcripts in antipsychotic-naïve vs. antipsychotic-exposed rats.

@article{Bartolomeis2016SwitchingAI,
  title={Switching antipsychotics: Imaging the differential effect on the topography of postsynaptic density transcripts in antipsychotic-na{\"i}ve vs. antipsychotic-exposed rats.},
  author={Andrea de Bartolomeis and Federica Marmo and Elisabetta Filomena Buonaguro and Gianmarco Latte and Carmine Tomasetti and Felice Iasevoli},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2016},
  volume={70},
  pages={24-38}
}
The postsynaptic density (PSD) has been regarded as a functional switchboard at the crossroads of a dopamine-glutamate interaction, and it is putatively involved in the pathophysiology of psychosis. Indeed, it has been demonstrated that antipsychotics may modulate several PSD transcripts, such as PSD-95, Shank, and Homer. Despite switching antipsychotics is… CONTINUE READING