Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review.
@article{Ruh2006SwitchingAA, title={Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review.}, author={H. Ruh{\'e} and J. Huyser and J. Swinkels and A. Schene}, journal={The Journal of clinical psychiatry}, year={2006}, volume={67 12}, pages={ 1836-55 } }
OBJECTIVE
Selective serotonin reuptake inhibitors (SSRIs) are frequently used as a first antidepressant for major depressive disorder but have response rates of 50% to 60% in daily practice. For patients with insufficient response to SSRIs, switching is often applied. This article aims to systematically review the evidence for switching pharmacotherapy after a first SSRI.
DATA SOURCES
A systematic literature search (updated until Feb. 10, 2005) in MEDLINE, EMBASE, CINAHL, and PsychINFO (all… CONTINUE READING
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