Switchable reactivity: the site-selective functionalization of trifluoromethyl-substituted pyrazoles

@inproceedings{Schlosser2002SwitchableRT,
  title={Switchable reactivity: the site-selective functionalization of trifluoromethyl-substituted pyrazoles},
  author={Michael Schlosser and Jean-No{\"e}l Volle and Fr{\'e}d{\'e}ric R. Leroux and Kurt Schenk},
  year={2002}
}
Modern organometallic methods enable the regioflexible conversion of simple heterocyclic starting materials into families of isomers and congeners. Depending on the choice of the reagent, 1-methyl-5-(trifluoromethyl)pyrazole undergoes deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached Me group. Similarly, 1-phenyl-5-(trifluoromethyl)pyrazole and 3-methyl-1-phenyl-5-(trifluoromethyl)pyrazole are selectively… CONTINUE READING

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