Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor.

@article{Fang2006SwitchTF,
  title={Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor.},
  author={Xiaolei Fang and Zhaoxu Liu and Yidong Fan and Chengyun Zheng and Sten Nilson and Lars Egevad and Peter Ekman and Dawei Xu},
  journal={International journal of cancer},
  year={2006},
  volume={118 10},
  pages={2485-9}
}
X-linked inhibitor of apoptosis protein (XIAP) suppresses apoptotic cell death by binding to caspases and inhibiting their functions, while the XIAP-associated factor1 (XAF1), a zinc finger protein, antagonizes XIAP activities, thereby promoting apoptosis. The aberrant silence of the XAF1 gene has recently been found in various types of cancer cells, which is suggested to be one of the potential mechanisms underlying survival advantages of malignant cells. In the present study, we investigated… CONTINUE READING

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