Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation.

@article{Leenaars2012SwitchtaskPI,
  title={Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation.},
  author={Cathalijn H. C. Leenaars and Ruud N.J.M.A. Joosten and Allard Zwart and Hans Sandberg and Emma M. Ruimschotel and Maaike A J Hanegraaf and Maurice Dematteis and Matthijs G. P. Feenstra and Eus J W Van Someren},
  journal={Sleep},
  year={2012},
  volume={35 2},
  pages={
          211-21
        }
}
STUDY OBJECTIVES Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we… CONTINUE READING
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