Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes.

@article{Gay2015SwitchlikeRO,
  title={Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes.},
  author={Austin Gay and Daphne Rye and Arun Radhakrishnan},
  journal={Biophysical journal},
  year={2015},
  volume={108 6},
  pages={
          1459-1469
        }
}
Many cellular processes are sensitive to levels of cholesterol in specific membranes and show a strongly sigmoidal dependence on membrane composition. The sigmoidal responses of the cholesterol sensors involved in these processes could arise from several mechanisms, including positive cooperativity (protein effects) and limited cholesterol accessibility (membrane effects). Here, we describe a sigmoidal response that arises primarily from membrane effects due to sharp changes in the chemical… CONTINUE READING
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High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS.

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