Switch in FOXA1 Status Associates with Endometrial Cancer Progression

  title={Switch in FOXA1 Status Associates with Endometrial Cancer Progression},
  author={Ingvild L\oberg Tangen and Camilla Krakstad and Mari Kylles\o Halle and Henrica Maria Johanna Werner and Anne Margrete \Oyan and Kanthida Kusonmano and Kjell Petersen and Karl Henning Kalland and Lars Andreas Akslen and Jone Trovik and Antoni Hurtado and Helga Birgitte Salvesen},
  booktitle={PloS one},
BACKGROUND The transcription factor Forkhead box A1 (FOXA1) is suggested to be important in hormone dependent cancers, although with little data for endometrial cancer. We investigated expression levels of FOXA1 in primary and metastatic endometrial cancer in relation to clinical phenotype, and transcriptional alterations related to FOXA1 status. METHODS Protein expression of FOXA1 was explored by immunohistochemistry in 529 primary and 199 metastatic endometrial carcinoma lesions. mRNA… CONTINUE READING


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