Switch between Large Hand-Over-Hand and Small Inchworm-like Steps in Myosin VI

  title={Switch between Large Hand-Over-Hand and Small Inchworm-like Steps in Myosin VI},
  author={So Nishikawa and Ikuo Arimoto and Keigo Ikezaki and Mitsuhiro Sugawa and Hiroshi Ueno and Tomotaka Komori and Atsuko Hikikoshi Iwane and Toshio Yanagida},
Many biological motor molecules move within cells using stepsizes predictable from their structures. Myosin VI, however, has much larger and more broadly distributed stepsizes than those predicted from its short lever arms. We explain the discrepancy by monitoring Qdots and gold nanoparticles attached to the myosin-VI motor domains using high-sensitivity nanoimaging. The large stepsizes were attributed to an extended and relatively rigid lever arm; their variability to two stepsizes, one large… CONTINUE READING


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