Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

@article{DeMarino2011SwinholideJA,
  title={Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei},
  author={Simona De Marino and Carmen Festa and Maria Valeria D'Auria and Thierry Cresteil and C{\'e}cile Debitus and Angela Zampella},
  journal={Marine Drugs},
  year={2011},
  volume={9},
  pages={1133 - 1141}
}
In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J… Expand
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