Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates.

@article{Kitikoon2009SwineIM,
  title={Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates.},
  author={Pravina Kitikoon and Amy L. Vincent and Bruce H. Janke and Britt Erickson and Erin L. Strait and Shan Yu and Marie Ren{\'e} Gramer and Eileen L. Thacker},
  journal={Vaccine},
  year={2009},
  volume={28 2},
  pages={523-31}
}
A swine influenza virus (SIV) vaccine-challenge pig model was used to study the potential of a conserved matrix 2 (M2) protein vaccine alone or in combination with an inactivated H1N1-vaccine to protect against H1N1 and H1N2 viruses. The H1N1-vaccine and heterologous H1N2-challenge virus model has previously been shown to prolong fever and increase SIV-associated pneumonic lesions. The M2 vaccine in combination with the H1N1-vaccine reduced the H1N2 induced fever but not virus shedding. The M2… CONTINUE READING

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