Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.

@article{Fan2016SwineTR,
  title={Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.},
  author={Wenchun Fan and Dong Yan Zhang and Ping Qian and Suhong Qian and Mengge Wu and Huanchun Chen and Xiangmin Li},
  journal={Antiviral research},
  year={2016},
  volume={127},
  pages={
          32-40
        }
}
The tripartite motif protein 21 (TRIM21) is a ubiquitously expressed E3 ubiquitin ligase and an intracellular antibody receptor. TRIM21 mediates antibody-dependent intracellular neutralization (ADIN) in cytosol and provides an intracellular immune response to protect host defense against pathogen infection. In this study, swine TRIM21 (sTRIM21) was cloned and its role in ADIN was investigated. The expression of sTRIM21 is induced by type I interferon in PK-15 cells. sTRIM21 restricts FMDV… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21

  • Antibodies
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

TRIM21—From Intracellular Immunity to Therapy

Stian Foss, Maria Bottermann, +3 authors Jan Terje Andersen
  • Front. Immunol.
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Intracellular Antibody Immunity

  • Journal of Clinical Immunology
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

TRIM famil

S. Nisole, J. P. Stoye, A. Saïb
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL