Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling.

@article{Shimizu2001SwiftIA,
  title={Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling.},
  author={Kazufumi Shimizu and P Y Bourillot and Soren J. Nielsen and Aaron M. Zorn and John Bertrand Gurdon},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 12},
  pages={3901-12}
}
Transforming growth factor beta (TGFbeta) signaling is transduced via Smad2-Smad4-DNA-binding protein complexes which bind to responsive elements in the promoters of target genes. However, the mechanism of how the complexes activate the target genes is unclear. Here we identify Xenopus Swift, a novel nuclear BRCT (BRCA1 C-terminal) domain protein that physically interacts with Smad2 via its BRCT domains. We examine the activity of Swift in relation to gene activation in Xenopus embryos. Swift… CONTINUE READING

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Physical and functional interaction of SMADs and p300/CBP.

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