Swift Intrahepatic Accumulation of Granulocytic Myeloid-Derived Suppressor Cells in a Humanized Mouse Model of Toxic Shock Syndrome.

@article{Szabo2016SwiftIA,
  title={Swift Intrahepatic Accumulation of Granulocytic Myeloid-Derived Suppressor Cells in a Humanized Mouse Model of Toxic Shock Syndrome.},
  author={Peter Anthony Szabo and Ankur Goswami and Arash Memarnejadian and Christiane L. Mallett and Paula J. Gareau Foster and John K McCormick and S M Mansour Haeryfar},
  journal={The Journal of infectious diseases},
  year={2016},
  volume={213 12},
  pages={1990-5}
}
Toxic shock syndrome (TSS) and other superantigen-mediated illnesses are associated with 'systemic' immunosuppression that jeopardizes the host's ability to fight pathogens. Here, we define a novel mechanism of 'local' immunosuppression that may benefit the host. Systemic exposure to staphylococcal enterotoxin B (SEB) rapidly and selectively recruited CD11b(+)Gr-1(high)Ly-6C(+) granulocytic myeloid-derived suppressor cells (MDSCs) to the liver of HLA-DR4 transgenic mice. Hepatic MDSCs inhibited… CONTINUE READING
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