Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

@article{Zofall2006Swi6HP1RA,
  title={Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.},
  author={Martin Zofall and Shiv I S Grewal},
  journal={Molecular cell},
  year={2006},
  volume={22 5},
  pages={
          681-92
        }
}
Heterochromatin formation is generally thought to result in transcriptional repression of target loci. However, RNAi-mediated heterochromatin assembly requires RNA polymerase II (Pol II) transcription. The mechanism facilitating Pol II accessibility to heterochromatin is unknown. We show that the fission yeast Epe1, a JmjC domain-containing protein and a negative regulator of heterochromatin, is distributed across all major heterochromatic domains and at certain meiotic genes. Remarkably, Epe1… CONTINUE READING
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