Swelling studies of gelatin. II: Effect of additives.

  title={Swelling studies of gelatin. II: Effect of additives.},
  author={Clyde M Ofner and Hans Schott},
  journal={Journal of pharmaceutical sciences},
  volume={76 9},
Interactions between gelatin and six cationic, anionic, and nonionic drugs or excipients were investigated through their effects on initial swelling rate and equilibrium swelling of gelatin. Short rectangular strips of Type B gelatin containing the additives were immersed in buffer solutions of pH 7.0 at 20 degrees C. Their weight gain due to uptake of buffer solution and their weight loss due to leaching of the additive and of gelatin were determined as a function of time. During preparation… Expand
Interaction of anionic compounds with gelatin. II: Effect on some physicochemical properties of gelatin.
The interaction of gelatin with four monosulfonated or monocarboxylated azo dyes was investigated by measuring the surface tension and intrinsic viscosity of gelatin solutions containing the dyes atExpand
Examination of self-crosslinked gelatin as a hydrogel for controlled release.
A gelatin matrix crosslinked by extensive dehydration was examined for use in controlled drug delivery in this preliminary investigation and the soluble, ionized form under conditions of maximum swelling and a possible drug-matrix repulsive interaction had the fastest release rate. Expand
Interaction of anionic compounds with gelatin. I: Binding studies.
This work deals with the interaction of gelatin and four monosulfonated or monocarboxylated azo dyes having hydrocarbon moieties of different sizes used as models for anionic drugs, which make up a significant percentage of all new drugs. Expand
Crosslinking studies in gelatin capsules treated with formaldehyde and in capsules exposed to elevated temperature and humidity.
The results support earlier reports of non-amino group crosslinking by formaldehyde in gelatin and support the possible mechanisms of this not-so-simple problem. Expand
Kinetics of swelling of polymers and their gels.
  • H. Schott
  • Materials Science, Medicine
  • Journal of pharmaceutical sciences
  • 1992
Theoretical considerations, based on diffusion-controlled swelling, show that first-order kinetics do not apply, even though deviations during the initial and even middle stages of the swelling process may be relatively small. Expand
Swelling behavior of hydrogels for colon‐site drug delivery
Hydrogels based on n-alkyl methacrylate esters (n-AMA), acrylic acid, and acrylamide crosslinked with 4,4′-di(methacryloylamino)azobenzene were prepared. Swelling behavior of the hydrogels wasExpand
Swelling kinetics of polymers
Abstract The equilibrium swelling of semicrystalline or crosslinked polymers and of their gels upon immersion in liquids has been investigated extensively. On the other hand, few studies have dealtExpand
Hydrogels for colon‐specific drug delivery: Swelling kinetics and mechanism of degradation in vitro
Hydrogels based on n-alkyl methacrylate esters (n-AMA) of various chain lengths, acrylic acid, and acrylamide crosslinked with 4,4'-di(methacryloylmino)azo-benzene were prepared. Swelling kineticsExpand
Investigation of aggregation behavior of ibuprofen sodium drug under the influence of gelatin protein and salt
Abstract The interaction of amphiphilic drug ibuprofen sodium salt (IBS) and gelatin (GT) protein have evaluated in the current system by means of conductometric, tensiometric and fluorometricExpand
Gliadin films. I: Preparation and in vitro evaluation as a carrier for controlled drug release
Abstract A method for the preparation of soft capsules (Gl.C) and chewable gums (GCG) of the hydrophobic wheat protein, crude gliadin, is reported. Gliadin films were found to be more hydrophilicExpand


Swelling studies of gelatin. I: Gelatin without additives.
The swelling rate and the equilibrium swelling of gelatin (type B) were studied by casting warm gelatin solutions into films, cutting them into short rectangular strips after gelation, drying them,Expand
Drug migration into soft gelatin capsule shells and its effect on in‐vitro availability
Solute release shows that both release and migration can be predicted from a knowledge of the aqueous solubility of the solute and its partition coefficient between water and the non‐polar solvent. Expand
Effect of inorganic additives on solutions of nonionic surfactants III: CMC's and surface properties.
The surfactants were octoxynol and polyoxyethylated oleyl alcohol, containing an average of 9.5 and 10 ethylene oxide units, respectively, and their CMC values were lowered by most electrolytes studied, representing salting out of the surfactant. Expand
Liquid and solid solution interactions of primary certified colorants with pharmaceutical gelatins.
A method for simulating a gelatin capsule shell wall was devised to examine solid-state interactions by visible and IR-attenuated total reflectance spectroscopy, dye release patterns, and the effect of the dyes on gelatin disintegration. Expand
Shifts in the apparent ionization constant of the carboxylic acid groups of gelatin.
Titration data of Type B gelatin were used to investigate shifts of the apparent ionization constant of the carboxylic acid groups caused by changes in the degree of ionization or net molecularExpand
Relationship of structure to properties in surfactants. III. Adsorption at the solid-liquid interface from aqueous solution
Surfactants adsorb onto solid substrates from aqueous solution by a number of different mechanisms: ion exchange, ion pairing, hydrogen bonding, physical adsorption by polarization or dispersionExpand
The Interaction of Bovine Plasma Albumin with Cationic Detergent. Studies by Binding Isotherm, Optical Rotation and Difference Spectrum
Binding isotherms were determined at pH 6.9 for systems of bovine plasma albumin (BPA) and cationic detergents at 25°C and 5 °C. Detergents used were: hexadecyltrimethylammonium bromide (HTAB),Expand
Soft gelatin capsules. I. Factors affecting capsule shell dissolution rate.
The gelatin disk method makes use of the current USP rotating-basket dissolution apparatus and shows the effects of agitation, temperature, dissolution medium, and shell composition on the capsule shell dissolution rate. Expand
The binding of deoxycholate and Triton X-100 to proteins.
The utility of deoxycholate and Triton X-100 for the solubilization of membrane proteins in native or near-native form is consistent with these results. Expand
Nonionic surface-active agents: II. Time dependence of micellar breakdown☆
Abstract The existence of nonequilibrium states in micellar solutions, described by Nash, has been confirmed in aqueous and nonaqueous solutions of nonionic surface-active agents by aExpand