Swelling-induced activation of Na+,K+,2Cl- cotransport in C6 glioma cells: kinetic properties and intracellular signalling mechanisms.

@article{Mongin1996SwellinginducedAO,
  title={Swelling-induced activation of Na+,K+,2Cl- cotransport in C6 glioma cells: kinetic properties and intracellular signalling mechanisms.},
  author={Alexander A Mongin and Sergei L Aksentsev and Sergei N. Orlov and Zinaida B Kvacheva and N. I. Mezen and Alexander S. Fedulov and Sergei V. Konev},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1285 2},
  pages={229-36}
}
Swelling of C6 glioma cells in hypotonic medium (180 mOsm) results in two- to three-fold activation of K+ (86Rb+) influx suppressed by 10 microM bumetanide. Bumetanide-sensitive transport of 86Rb+ is dependent on extracellular K+, Na+ and Cl- both in iso-osmotic conditions and under hypo-osmotic shock, supporting the notion that it is mediated by Na+,K+,2Cl- cotransport. Inhibitors of protein kinase C (10 microM polymyxin B and l microM staurosporine) had no significant effect on basal… CONTINUE READING

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