Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release.

@article{Schlichter2011SwellingAC,
  title={Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release.},
  author={Lyanne C Schlichter and Timothy Mertens and Baosong Liu},
  journal={Channels},
  year={2011},
  volume={5 2},
  pages={128-37}
}
Microglia have a swelling-activated Cl- current (which we call IClswell), and while some of its biophysical properties and functional roles have been elucidated, its molecular identity is unknown. To relate this current to cell functions and determine whether it is regulated by mechanisms other than cell swelling, it is important to establish both biophysical and pharmacological fingerprints. Here, we used rat microglia and a cell line derived from them (MLS-9) to study biophysical, regulatory… CONTINUE READING
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