Sweet Taste Signaling Functions as a Hypothalamic Glucose Sensor

  title={Sweet Taste Signaling Functions as a Hypothalamic Glucose Sensor},
  author={Xueying Ren and Ligang Zhou and Rose Marie Z. Terwilliger and Samuel Sathyanesan Newton and Ivan E T de Araujo},
  booktitle={Front. Integr. Neurosci.},
Brain glucosensing is essential for normal body glucose homeostasis and neuronal function. However, the exact signaling mechanisms involved in the neuronal sensing of extracellular glucose levels remain poorly understood. Of particular interest is the identification of candidate membrane molecular sensors that would allow neurons to change firing rates independently of intracellular glucose metabolism. Here we describe for the first time the expression of the taste receptor genes Tas1r1, Tas1r2… CONTINUE READING
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