Swarming-coupled expression of the Proteus mirabilis hpmBA haemolysin operon.

@article{Fraser2002SwarmingcoupledEO,
  title={Swarming-coupled expression of the Proteus mirabilis hpmBA haemolysin operon.},
  author={Gillian M. Fraser and Laurent Claret and Richard Furness and Srishti Gupta and Colin Hughes},
  journal={Microbiology},
  year={2002},
  volume={148 Pt 7},
  pages={2191-201}
}
The HpmA haemolysin toxin of Proteus mirabilis is encoded by the hpmBA locus and its production is upregulated co-ordinately with the synthesis and assembly of flagella during differentiation into hyperflagellated swarm cells. Primer extension identified a sigma(70) promoter upstream of hpmB that was upregulated during swarming. Northern blotting indicated that this promoter region was also required for concomitant transcription of the immediately distal hpmA gene, and that the unstable hpmBA… CONTINUE READING

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