Swapping Small Ubiquitin-like Modifier (SUMO) Isoform Specificity of SUMO Proteases SENP6 and SENP7*

@article{Alegre2011SwappingSU,
  title={Swapping Small Ubiquitin-like Modifier (SUMO) Isoform Specificity of SUMO Proteases SENP6 and SENP7*},
  author={K. O. Alegre and D. Reverter},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={36142 - 36151}
}
  • K. O. Alegre, D. Reverter
  • Published 2011
  • Biology, Medicine
  • The Journal of Biological Chemistry
    • Background: The SENP/ULP family of SUMO proteases display different cleavage preference for SUMO isoforms. Results: Insights into the structural determinants for the preference of SENP6 and SENP7 for the SUMO2/3 isoform. Conclusion: A novel interface between SENP6 or SENP7 and SUMO determines the SUMO isoform preference. Significance: This may be the first time that the cleavage preference between SUMO1 and SUMO2/3 was swapped by single point mutagenesis. SUMO proteases can regulate the amounts… CONTINUE READING
    View on ASBMB
    jbc.org
    20 Citations
    Highly Influencial Citations
    2
    Background Citations
    9
    Methods Citations
    2
    Results Citations
    1
    20 Citations
    Citation Type

    Citation Type

    Structural insights into the SENP6 Loop1 structure in complex with SUMO2
    • 6
    A Novel SUMO1-specific Interacting Motif in Dipeptidyl Peptidase 9 (DPP9) That Is Important for Enzymatic Regulation*
    • 43
    • PDF
    SUMO-specific proteases and isopeptidases of the SENP family at a glance
    • 53
    • PDF
    The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics.
    • 10
    SUMO targeting of a stress-tolerant Ulp1 SUMO protease
    • 2
    • PDF
    Function and regulation of SUMO proteases
    • 400
    Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)
    • 3
    Differential expression of SUMO-specific protease 7 variants regulates epithelial–mesenchymal transition
    • 44
    • PDF
    Structural and functional analysis of SMO-1, the SUMO homolog in Caenorhabditis elegans
    • 3
    • PDF
    SUMOylation in carcinogenesis.
    • 129

    References

    SHOWING 1-10 OF 36 REFERENCES
    Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7*
    • 106
    • PDF
    The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.
    • 113
    • PDF
    Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*
    • 219
    • PDF
    SUMO protease SENP1 induces isomerization of the scissile peptide bond
    • 96
    • PDF
    A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.
    • 169
    Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.
    • 69
    • PDF
    The SUMO-Specific Protease SENP5 Is Required for Cell Division
    • 162
    • PDF
    Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease.
    • 52
    • PDF
    Small Ubiquitin-related Modifier (SUMO)-specific Proteases
    • 131
    • PDF
    Characterization of SENP7, a SUMO-2/3-specific isopeptidase.
    • 88
    • PDF