Suvorexant for the treatment of insomnia

@article{Jacobson2014SuvorexantFT,
  title={Suvorexant for the treatment of insomnia},
  author={Laura H. Jacobson and Gabrielle E. Callander and Daniel Hoyer},
  journal={Expert Review of Clinical Pharmacology},
  year={2014},
  volume={7},
  pages={711 - 730}
}
Suvorexant (Belsorma®) is the first orexin receptor antagonist approved by the US FDA (August 2014) for insomnia treatment. Following comprehensive Phase II/III studies, with up to 12 months of treatment in adult and elderly patients, there is little doubt that suvorexant induces and maintains sleep. However, the FDA and sponsor disagreed about effective versus safe doses (November 2012). The FDA considered that 5–15 mg were efficient and probably safe, whereas the sponsors had proposed 15–40… 

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