Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

@inproceedings{Kishi2015SuvorexantFP,
  title={Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials},
  author={Taro Kishi and Shinji Matsunaga and Nakao Iwata and Gianni Virgili},
  booktitle={PloS one},
  year={2015}
}
OBJECTIVE We performed a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials evaluating suvorexant for primary insomnia. METHODS Relevant studies were identified through searches of PubMed, databases of the Cochrane Library, and PsycINFO citations through June 27, 2015. We performed a systematic review and meta-analysis of suvorexant trial efficacy and safety outcomes. The primary efficacy outcomes were either subjective total sleep time (sTST) or… CONTINUE READING

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Suvorexant caused a higher incidence than placebo of at least one side effects , abnormal dreams , somnolence , excessive daytime sleepiness / sedation , fatigue , dry mouth , and rebound insomnia .
Suvorexant caused a higher incidence than placebo of at least one side effects , abnormal dreams , somnolence , excessive daytime sleepiness / sedation , fatigue , dry mouth , and rebound insomnia .
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