Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats.

@article{Yang2014Suv39h1PF,
  title={Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats.},
  author={Bo Yang and Jian Yang and Jing Bai and Peng Pu and Jun Liu and Fang Wang and Bing Ruan},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2014},
  volume={33 4},
  pages={1176-85}
}
BACKGROUND Patients with diabetes are at increased risk of ischemic events. Suv39h1 is a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9, which is associated with the suppression of inflammatory genes in diabetes. However, the role of Suv39h1 in myocardial ischemia/reperfusion (I/R) injury under diabetic condition has not been evaluated. METHODS To generate diabetic model, male SD rats were fed with 60% fat diet followed by intraperitoneal injection with 40mg/kg… CONTINUE READING