Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vector.

@article{Folliot2003SustainedTT,
  title={Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vector.},
  author={S{\'e}bastien Folliot and Delphine Briot and Herv{\'e} Conrath and Nathalie Provost and Yan Ch{\'e}rel and Philippe Moullier and Fabienne Rolling},
  journal={The journal of gene medicine},
  year={2003},
  volume={5 6},
  pages={493-501}
}
BACKGROUND Viral vector delivery of neurotrophic-expressing transgenes in the retina may retard or prevent the onset of blindness associated with photoreceptor degeneration. A key safety issue is to achieve regulated expression of these genes in the retina. The purpose of our study was to evaluate whether a single recombinant AAV-2 (rAAV) encoding for a tetracycline (Tet)-regulated destabilized reporter gene could provide quantitative profiles of gene regulation targeted to the rat neuroretina… CONTINUE READING
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