Sustained suppression of Fas ligand expression in cisplatin-resistant human ovarian surface epithelial cancer cells


Although cisplatin derivatives are first line chemotherapeutic agents for the treatment of ovarian epithelial cancer, chemoresistance is a major therapeutic problem. Although the cytotoxic effect of these agents are believed to be mediated through the induction of apoptosis, the role of the Fas/FasL system in chemoresistance in human ovarian epithelial… (More)
DOI: 10.1023/A:1026456926754


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