Sustained-release theophylline reduces dyspnea in nonreversible obstructive airway disease.

@article{Mahler1985SustainedreleaseTR,
  title={Sustained-release theophylline reduces dyspnea in nonreversible obstructive airway disease.},
  author={Donald A. Mahler and Richard A. Matthay and Petra Snyder and Carolyn K Wells and Jacob Loke},
  journal={The American review of respiratory disease},
  year={1985},
  volume={131 1},
  pages={22-5}
}
Although orally administered theophylline has been prescribed widely in patients with nonreversible airway obstruction, symptomatic benefit has not been established. To assess the effects of orally administered theophylline on dyspnea, we performed a randomized, double-bind, crossover, placebo-theophylline clinical trial in 12 ambulatory male patients with moderate to severe nonreversible airway obstruction. Dyspnea was rated using 2 clinical indexes based on 3 components affecting… CONTINUE READING