Sustained-release theophylline and nocturnal asthma, once-daily and unequal dosing schedules.

@article{Smolensky1987SustainedreleaseTA,
  title={Sustained-release theophylline and nocturnal asthma, once-daily and unequal dosing schedules.},
  author={Michael hale Smolensky and Gilbert E. D'Alonzo and Gert Kunkel and Peter J Barnes},
  journal={Chronobiology international},
  year={1987},
  volume={4 3},
  pages={459-66}
}
Many asthmatic patients experience aggravation of symptoms overnight resulting in disruption of their sleep. Sustained-release theophylline represents at this time a major bronchodilator medication which possesses a sufficient duration of activity to avert the nocturnal breathing distress of asthma. Circadian rhythm-adapted theophylline schedules consisting of unequal dosing--more or all the drug taken in the evening--have proven efficacious in clinical investigations for certain patients… CONTINUE READING

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