Sustained release of lidocaine from Poloxamer 407 gels.

  title={Sustained release of lidocaine from Poloxamer 407 gels.},
  author={Eduardo Ricci and Laureluci O Lunardi and Denise M A Nanclares and Juliana Maldonado Marchetti},
  journal={International journal of pharmaceutics},
  volume={288 2},
In this work, we show that alteration of P407 gel content can affect drug release rates. The inorganic salts and PEG 400 commonly included in the formulation of P407 gels can also change the rate at which a drug is released. Lidocaine was selected as a model drug because, although widely used in the treatment of pain, its use is limited by short duration of its effects. The use of P407 gels prolongs the residence time of the lidocaine at the injection site, sustains drug release and increases… CONTINUE READING


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