Sustained release of hydroxycamptothecin after subcutaneous administration using a novel phospholipid complex-DepoFoam technology.

@article{Zhao2010SustainedRO,
  title={Sustained release of hydroxycamptothecin after subcutaneous administration using a novel phospholipid complex-DepoFoam technology.},
  author={Yue Zhao and Jie Liu and Xun Sun and Zhi-Rong Zhang and Tao Gong},
  journal={Drug development and industrial pharmacy},
  year={2010},
  volume={36 7},
  pages={
          823-31
        }
}
OBJECTIVE In order to prolong the duration of drug in the circulation, multivesicular liposome (MVL, namely DepoFoam) was utilized as a sustained-release delivery system for hydroxycamptothecin (HCPT). METHODS HCPT is insoluble in both water and physiological acceptable organic solvents; therefore, HCPT-phospholipid complex (HCPT-PCC) was prepared by solvent evaporation method to improve its liposolubility. In this study, preparation, characterization, in vitro release, and in vivo… CONTINUE READING