Sustained release of erythropoietin using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia.


OBJECTIVES We hypothesized that erythropoietin (EPO)-immersed gelatin hydrogel microspheres (GHM) injected into ischemic legs might continuously release a small amount of EPO to locally stimulate angiogenesis without unfavorable systemic effects. BACKGROUND EPO is a potent angiogenic factor, but its use for relieving ischemic organs is limited because of… (More)
DOI: 10.1016/j.jacc.2009.02.056


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