Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model.

Abstract

The use of pro-angiogenic growth factors in ischemia models has been associated with limited success in the clinical setting, in part owing to the short lived effect of the injected cytokine. The use of a microparticle system could allow localized and sustained cytokine release and consequently a prolonged biological effect with induction of tissue… (More)
DOI: 10.1016/j.jconrel.2010.07.097

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@article{Formiga2010SustainedRO, title={Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model.}, author={Fabio Rocha Formiga and Beatriz Pelacho and Elisa Garbayo and Gloria Abizanda and Ju{\'a}n Jos{\'e} Gavira and Teresa Simon-Yarza and Manuel Mazo and Esther H Tamayo and Carlos Jauquicoa and Carlos Ortiz-de-Solorzano and Felipe Pr{\'o}sper and Mar{\'i}a Jos{\'e} Blanco-Pr{\'i}eto}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2010}, volume={147 1}, pages={30-7} }