Sustained release of ATP encapsulated in chitosan oligosaccharide nanoparticles.

  title={Sustained release of ATP encapsulated in chitosan oligosaccharide nanoparticles.},
  author={Yongzhong Du and Xiao-ying Ying and Ling Wang and You Zhai and Hong Yuan and Ri-Sheng Yu and Fuqiang Hu},
  journal={International journal of pharmaceutics},
  volume={392 1-2},
The chemical cross-linked chitosan oligosaccharide (CSO) nanoparticles containing ATP/CSO ionic complex nano-components were prepared using combination techniques of W/O miniemulsion, chemical cross-linking and ionic complexation. The resulted nanoparticles had about 110 nm diameter and 20 mV surface zeta potential. The ATP loading efficiencies in nanoparticles could reach up to 40.6-69.5%. It was found that the ATP loading efficiency increased with increasing the amount and the molecular… CONTINUE READING

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L. Wang, H. Yuan, X. H. Wei, F. Q. Hu
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