Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites.

@article{Friedman2008SustainedRN,
  title={Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites.},
  author={Adam J. Friedman and George Han and Mahantesh S Navati and Manju Chacko and Leslie Gunther and Alan Alfieri and Joel M. Friedman},
  journal={Nitric oxide : biology and chemistry},
  year={2008},
  volume={19 1},
  pages={12-20}
}
A new platform using biocompatible materials is presented for generating powders comprised of nanoparticles that release therapeutic levels of nitric oxide (NO) in a controlled and sustained manner. The capacity of these particles to retain and gradually release NO arises from their having combined features of both glassy matrices and hydrogels. This feature allows both for the generation of NO through the thermal reduction of added nitrite by glucose and for the retention of the generated NO… CONTINUE READING

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