Sustained-release applications of montmorillonite interaction with amphetamine sulfate.

@article{McGinity1977SustainedreleaseAO,
  title={Sustained-release applications of montmorillonite interaction with amphetamine sulfate.},
  author={James W. McGinity and John L. Lach},
  journal={Journal of pharmaceutical sciences},
  year={1977},
  volume={66 1},
  pages={63-6}
}
Urinary recovery studies showed that montmorillonite significantly affects the initial therapeutic levels of amphetamine sulfate. The combination of a 1:20 drug-montmorillonite complex with pure drug in a 1:1 ratio, based on amphetamine content, resulted in recovery profiles resembling those obtained from prolonged-release dosage forms. The 1:20 complex, pure drug, and combination formulations showed comparable bioavailability after 48 hr. 

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