Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis

@article{Gual2000SustainedRO,
  title={Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis},
  author={Philippe Gual and Silvia Giordano and Tracy Ann Williams and St{\'e}phane Rocchi and Emmanuel Van Obberghen and Paolo Maria Comoglio},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={1509-1518}
}
A distinctive property of Hepatocyte Growth Factor (HGF) is its ability to induce differentiation of tubular structures from epithelial and endothelial cells (branching tubulogenesis). The HGF receptor directly activates PI3 kinase, Ras and STAT signalling pathways and phosphorylates the adaptator GRB2 Associated Binder-1 (Gab1). Gab1 is also phosphorylated in response to Epidermal Growth Factor (EGF) but is unable to induce tubule formation. Comparison of 32P-peptide maps of Gab1 from EGF… CONTINUE READING