Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome.

@article{Wu2009SustainedOS,
  title={Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome.},
  author={Ming-xing Wu and Qingning Bian and Yizhi Liu and Alexandre Furtado Fernandes and Allen Taylor and Paulo C.M. Pereira and F M Shang},
  journal={Free radical biology & medicine},
  year={2009},
  volume={46 1},
  pages={62-9}
}
NF-kappaB is a family of important transcription factors involved in many cellular functions, such as cell survival, proliferation, and stress responses. Many studies indicate that NF-kappaB is a stress-sensitive transcription factor and its activation is regulated by reactive oxygen species. In previous studies, we and others demonstrated that this transcription factor can be activated by transient oxidative stress. However, the effects of sustained oxidative stress on NF-kappaB activation are… CONTINUE READING

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