Sustained norepinephrine stimulation induces different regulation of expression in three alpha1-adrenoceptor subtypes.

@article{Lei2001SustainedNS,
  title={Sustained norepinephrine stimulation induces different regulation of expression in three alpha1-adrenoceptor subtypes.},
  author={Beilei Lei and Y Jonathan Zhang and Chide Han},
  journal={Life sciences},
  year={2001},
  volume={69 3},
  pages={301-8}
}
The norepinephrine (NE)-induced regulation of alpha1-adrenoceptors (ARs) expression in human embryonic kidney (HEK) 293 cells stably expressing cloned alpha1-AR subtypes with similar receptor densities was investigated. In the presence of 10 microM propranolol, the treatment of cells with 10 microM NE for 4-72 h down-regulated alpha1A- and alpha1D-AR. but… CONTINUE READING