Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.

@article{Lagoda2014SustainedNO,
  title={Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.},
  author={Gwen A. Lagoda and Sena F. Sezen and Kenneth J. Hurt and Marcelo Rodrigues Cabrini and Dillip Kumar Mohanty and Arthur L. Burnett},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 1},
  pages={76-84}
}
We evaluated the therapeutic potential of a sustained nitric oxide (NO)-releasing compound to correct the molecular hallmarks and pathophysiology of priapism, an important but poorly characterized erectile disorder. 1,5-Bis-(dihexyl-N-nitrosoamino)-2,4-dinitrobenzene (C6') and an inactive form of the compound [1,5-bis-(dihexylamino)-2,4-dinitrobenzene (C6)] were tested in neuronal cell cultures and penile lysates for NO release (Griess assay) and biological activity (cGMP production). The… CONTINUE READING