Sustained neuronal activity generated by glial plasticity.

@article{Pirttimaki2011SustainedNA,
  title={Sustained neuronal activity generated by glial plasticity.},
  author={Tiina Maria Pirttimaki and S. D. Hall and H. Rheinallt Parri},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 21},
  pages={7637-47}
}
Astrocytes release gliotransmitters, notably glutamate, that can affect neuronal and synaptic activity. In particular, astrocytic glutamate release results in the generation of NMDA receptor (NMDA-R)-mediated slow inward currents (SICs) in neurons. However, factors underlying the emergence of SICs and their physiological roles are essentially unknown. Here we show that, in acute slices of rat somatosensory thalamus, stimulation of lemniscal or cortical afferents results in a sustained increase… CONTINUE READING

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