Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner.

@article{Yue2008SustainedMT,
  title={Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner.},
  author={Xu Yue and Suneeta Tumati and Edita Navratilova and Dagmar Strop and Paul A St john and Todd W. Vanderah and W. R{\"o}ske and Henry I. Yamamura and Eva V Varga},
  journal={European journal of pharmacology},
  year={2008},
  volume={584 2-3},
  pages={272-7}
}
Recent studies suggest that sustained morphine-mediated paradoxical pain may play an important role in the development of analgesic tolerance. The intracellular signal transduction pathways involved in sustained opioid mediated augmentation of spinal pain neurotransmitter (such as calcitonin gene-related peptide (CGRP)) release are not fully clarified. Cyclic AMP (cAMP)-dependent protein kinase (PKA) plays an important role in the modulation of presynaptic neurotransmitter release. Moreover, we… CONTINUE READING