Sustained low-efficiency dialysis with filtration (SLEDD-f) in the management of acute sodium valproate intoxication.


Hemodialysis is only infrequently used in drug overdosage situations. The efficacy of hemodialysis to remove the drug depends upon the pharmacokinetics and pharmacodynamics of the drug. At normal therapeutic concentrations, valproic acid is predominantly protein bound and therefore removal by hemodialysis is limited. In an overdose situation, protein… (More)
DOI: 10.1111/j.1542-4758.2008.00254.x


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