Sustained levels of stress or glucocorticoids also damage the hippocampus at the level of morphological neuroplasticity ( reviewed in Sapolsky , 2000 ) ( Figure 2 ) . Excess glucocorticoids ( Woolley et al , 1990 )

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we provide an overview of the evidence that chronic stress, which can precipitate or exacerbate depression, disrupts neuroplasticity, while antidepressant treatment produces opposing… CONTINUE READING