Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice.

@article{Coomber2010SustainedLO,
  title={Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice.},
  author={Ben Coomber and Claire L Gibson},
  journal={Brain research},
  year={2010},
  volume={1361},
  pages={124-32}
}
Female gender, which is abolished following ovariectomy and reproductive senescence, is associated with improved outcome following cerebral stroke. Estrogen replacement partially restores this benefit of the female gender but the effect of progesterone in hormone-deficient animals is currently unknown. We evaluated various outcomes following middle cerebral artery occlusion (MCAO) in ovariectomised female mice, with a physiologically relevant restoration of progesterone levels. Ovariectomised… CONTINUE READING

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Progesterone pharmacokinetics in the mouse: implications for potential stroke therapy.

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