Sustained indomethacin and ranitidine with intermittent continuous infusion interleukin-2 in advanced malignant melanoma: a phase II study.

@article{Mertens1993SustainedIA,
  title={Sustained indomethacin and ranitidine with intermittent continuous infusion interleukin-2 in advanced malignant melanoma: a phase II study.},
  author={Wilson Mertens and Vivien H. C. Bramwell and Diponkar Banerjee and Femida Gwadry-Sridhar and P. K. Lala},
  journal={Clinical oncology (Royal College of Radiologists (Great Britain))},
  year={1993},
  volume={5 2},
  pages={107-13}
}
Experimental work has shown that, during the development of tumours, host macrophages are triggered to produce high levels of prostaglandin E2 which inactivates natural killer cells and suppresses lymphokine activated killer cell development. Sustained, uninterrupted indomethacin treatment, when combined with interleukin-2 (IL-2), can totally eradicate experimental metastases. Most trials utilizing high dose IL-2 employ indomethacin and ranitidine in order to alleviate or prevent IL-2 toxicity… CONTINUE READING