Sustained improvement of motor function in hemiparkinsonian rats chronically treated with low doses of caffeine or trihexyphenidyl

@article{BataGarca2007SustainedIO,
  title={Sustained improvement of motor function in hemiparkinsonian rats chronically treated with low doses of caffeine or trihexyphenidyl},
  author={Jos{\'e} L. Bata-Garc{\'i}a and Jairo Villanueva-Toledo and Gabriel Guti{\'e}rrez-Ospina and Fernando Jos{\'e} {\'A}lvarez-Cervera and Francisco J. Heredia-L{\'o}pez and Jos{\'e}L. G{\'o}ngora-Alfaro},
  journal={Pharmacology Biochemistry and Behavior},
  year={2007},
  volume={86},
  pages={68-78}
}
The effects of chronic oral treatment with low doses of caffeine (1-3 mg/kg) and trihexyphenidyl (0.1-0.2 mg/kg) were tested on hemiparkinsonian rats, which received the following treatments in a counterbalanced order: vehicle, caffeine, trihexyphenidyl, and caffeine plus trihexyphenidyl. Three preclinical models were used: the stepping test, the cylinder test, and the staircase test. Compared to pre-lesion values, the forepaw contralateral to the dopamine-denervated side showed impaired… Expand
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