Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment.

@article{Burke2009SustainedHP,
  title={Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment.},
  author={Danielle L. Burke and Maria G. Frid and Cl{\'a}udia Laura Barberio Kunrath and Vijaya Karoor and Adil A Anwar and Brandie D. Wagner and Derek Strassheim and Kurt R Stenmark},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2009},
  volume={297 2},
  pages={L238-50}
}
Recent studies demonstrate that sustained hypoxia induces the robust accumulation of leukocytes and mesenchymal progenitor cells in pulmonary arteries (PAs). Since the factors orchestrating hypoxia-induced vascular inflammation are not well-defined, the goal of this study was to identify mediators potentially responsible for recruitment to and retention and differentiation of circulating cells within the hypoxic PA. We analyzed mRNA expression of 44 different chemokine/chemokine receptor… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

The vagus nerve alters the pulmonary dendritic cell response to injury.

The Journal of surgical research • 2014
View 11 Excerpts
Highly Influenced

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.

American journal of physiology. Lung cellular and molecular physiology • 2018
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension.

American journal of respiratory and critical care medicine • 2008
View 8 Excerpts
Highly Influenced

Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension.

The European respiratory journal • 2007
View 7 Excerpts
Highly Influenced

Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease.

Arteriosclerosis, thrombosis, and vascular biology • 2007
View 4 Excerpts
Highly Influenced

The role of circulating fibrocytes in fibrosis.

Current rheumatology reports • 2006
View 7 Excerpts
Highly Influenced

Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease.

American journal of respiratory cell and molecular biology • 2004
View 4 Excerpts
Highly Influenced

Chemokines in vascular dysfunction and remodeling.

Arteriosclerosis, thrombosis, and vascular biology • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…