Sustained hypoxia-induced proliferation of carotid body type I cells in rats.

@article{Wang2008SustainedHP,
  title={Sustained hypoxia-induced proliferation of carotid body type I cells in rats.},
  author={Zun-yi Wang and Edward Olson and Dale E. Bjorling and Gordon S Mitchell and Gerald E. Bisgard},
  journal={Journal of applied physiology},
  year={2008},
  volume={104 3},
  pages={803-8}
}
Sustained hypoxia (SH) has been shown to cause profound morphological and cellular changes in carotid body (CB). However, results regarding whether SH causes CB type I cell proliferation are conflicting. By using bromodeoxyuridine, a uridine analog that is stably incorporated into cells undergoing DNA synthesis, we have found that SH causes the type I cell proliferation in the CB; the proliferation occurs mainly during the first 1-3 days of hypoxic exposure. Moreover, the new cells survive for… CONTINUE READING

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